Small open-label study: Tadalafil decreases estrogen in lean men after 12 months. T and fT unaffected. No effect in obese
https://www.ncbi.nlm.nih.gov/pubmed/16839328
In vitro study: Tadalafil decreases aromatase activity and increases androgen receptor expression.
https://www.ncbi.nlm.nih.gov/pubmed/26134065
No rise in testosterone after 2 months of 5mg daily of tadalafil
https://www.ncbi.nlm.nih.gov/pubmed/23173697
Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization.
https://www.ncbi.nlm.nih.gov/pubmed/28133708
Open label retrospective study: 20mg of tadalfil used on demand increases testosterone more than 50mg viagra
https://www.ncbi.nlm.nih.gov/pubmed/15355456
- Effect attributed by researchers to the higher frequency of full sexual intercourse in the Tad-treated group. This is not automatically true. Perhaps blood flow is also an issue.
If you don't respond to tadalafil every now and again - daily dosing might help**
https://www.ncbi.nlm.nih.gov/pubmed/23841532
REVIEW: tadalafil works for benign prostatic hyperplasia
https://www.ncbi.nlm.nih.gov/pubmed/25083163
REVIEW: Phosphodiesterase Type 5 Inhibitors work for BHP
https://www.ncbi.nlm.nih.gov/pubmed/26806655
https://www.ncbi.nlm.nih.gov/pubmed/23937669
Rat study: Yes, tadalafil can actually shrink the prostate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305204/
