Nitric Oxide

In vitro study: Nitric Oxide (NO) can stimulate the release of GnRH (LHRH) in hypothalamus cells
- Dose dependent effect
- An NO donor (sodium nitroprusside) increased GnRH in a dose dependent manner.
- This exposure increased intracellular and extracellular cGMP.
- Exposure of cells to a cGMP analog (8-Br-cGMP) also stimulated GnRH production.

Ascorbic acid (Vitamin C) acts as an inhibitory transmitter in the hypothalamus to inhibit stimulated luteinizing hormone-releasing hormone release by scavenging nitric oxide.

Role of nitric oxide in the control of luteinizing hormone-releasing hormone release in vivo and in vitro.

The role of nitric oxide (NO) in control of hypothalamic-pituitary function.

Nitric oxide mediates sexual behavior in female rats.