Forskolin activates cAMP

Forskolin as a vasodilator
"cAMP-dependent vasodilator forskolin remained unchanged"

This in vitro study found that forskolin boosts testosterone production

In vitro study - ditto.

In fat men forskolin increases testosterone… but not significantly.;jsessionid=ACA9D6579BE6093271D030A566E23BA8.f02t04
The actual change in serum total testosterone concentration was not significantly different among groups, but it increased 16.77 +/- 33.77% in the forskolin group compared with a decrease of 1.08 +/- 18.35% in the placebo group.

Forskolin supresses Type 1 5AR in mouse testes… but this type of 5AR seems to produce androstanediol anyway!
Unclear relevance!




Forskolin upregulates aromatase in a particular carcinoma cell line
Unclear relevance! Different factors may be present in non cancerous cells e.g. there are different promoters. Promoter II vs Promoter I.4 in noncancerous cells.

And… Forskolin does not have an effect on Promoter I.4… unless dexamethasone is present (then it's synergistic in increases)
dexamethasone is a pharmacutical drug

But what is going on here?

Liver damage

Dietary Coleus forskohlii extract generates dose-related hepatotoxicity in mice. Pure Forskolin is fine… it's the other parts of the root that are the problem.

Weight Loss

coleus forskohlii
"Results suggest that CF does not appear to promote weight loss but may help mitigate weight gain in overweight females with apparently no clinically significant side effects."

DHT may be synergistic with forskolin in terms of fat loss.

Seems to reduce rat appetite

Effect on Prolactin

Possible prolactin booster - possible