Forskolin activates cAMP
https://www.ncbi.nlm.nih.gov/pubmed/22393824
Forskolin as a vasodilator
https://www.ncbi.nlm.nih.gov/pubmed/7814613?access_num=7814613&link_type=MED&dopt=Abstract
"cAMP-dependent vasodilator forskolin remained unchanged"
This in vitro study found that forskolin boosts testosterone production
https://www.ncbi.nlm.nih.gov/pubmed/11500963
In vitro study - ditto.
https://www.ncbi.nlm.nih.gov/pubmed/21823337
In fat men forskolin increases testosterone… but not significantly.
http://onlinelibrary.wiley.com/doi/10.1038/oby.2005.162/abstract;jsessionid=ACA9D6579BE6093271D030A566E23BA8.f02t04
The actual change in serum total testosterone concentration was not significantly different among groups, but it increased 16.77 +/- 33.77% in the forskolin group compared with a decrease of 1.08 +/- 18.35% in the placebo group.
http://www.jbc.org/content/271/33/19900.short
Forskolin supresses Type 1 5AR in mouse testes… but this type of 5AR seems to produce androstanediol anyway!
Unclear relevance!
https://repositories.tdl.org/utswmed-ir/handle/2152.5/755
READ: https://www.ncbi.nlm.nih.gov/pubmed/16281505
READ: https://www.ncbi.nlm.nih.gov/pubmed/20432242
Aromatase
Forskolin upregulates aromatase in a particular carcinoma cell line
https://www.ncbi.nlm.nih.gov/pubmed/14709151
Unclear relevance! Different factors may be present in non cancerous cells e.g. there are different promoters. Promoter II vs Promoter I.4 in noncancerous cells.
And… Forskolin does not have an effect on Promoter I.4… unless dexamethasone is present (then it's synergistic in increases)
https://www.ncbi.nlm.nih.gov/pubmed/21722693
dexamethasone is a pharmacutical drug https://en.wikipedia.org/wiki/Dexamethasone
But what is going on here? https://www.ncbi.nlm.nih.gov/pubmed/2821057
Liver damage
Dietary Coleus forskohlii extract generates dose-related hepatotoxicity in mice. Pure Forskolin is fine… it's the other parts of the root that are the problem.
https://www.ncbi.nlm.nih.gov/pubmed/22729658
Weight Loss
coleus forskohlii
https://www.ncbi.nlm.nih.gov/pubmed/18500958
"Results suggest that CF does not appear to promote weight loss but may help mitigate weight gain in overweight females with apparently no clinically significant side effects."
DHT may be synergistic with forskolin in terms of fat loss.
https://www.ncbi.nlm.nih.gov/pubmed/18801408
Seems to reduce rat appetite
https://www.ncbi.nlm.nih.gov/pubmed/24497741
https://www.ncbi.nlm.nih.gov/pubmed/26593941
Effect on Prolactin
Possible prolactin booster - possible
https://www.drugs.com/breastfeeding/coleus.html